Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing
Joint Authors
Hermenegildo, C.
Novella, Susana
Pérez-Cremades, Daniel
Mompeón, Ana
Vidal-Gómez, Xavier
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-20
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cardiovascular diseases are a worldwide health problem and are the leading cause of mortality in developed countries.
Together with experimental data, the lower incidence of cardiovascular diseases in women than in men of reproductive age points to the influence of sex hormones at the cardiovascular level and suggests that estrogens play a protective role against cardiovascular disease and that this role is also modified by ageing.
Estrogens affect cardiovascular function via their specific estrogen receptors to trigger gene expression changes at the transcriptional level.
In addition, emerging studies have proposed a role for microRNAs in the vascular effects mediated by estrogens.
miRNAs regulate gene expression by repressing translational processes and have been estimated to be involved in the regulation of approximately 30% of all protein-coding genes in mammals.
In this review, we highlight the current knowledge of the role of estrogen-sensitive miRNAs, and their influence in regulating vascular ageing.
American Psychological Association (APA)
Pérez-Cremades, Daniel& Mompeón, Ana& Vidal-Gómez, Xavier& Hermenegildo, C.& Novella, Susana. 2018. Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211745
Modern Language Association (MLA)
Pérez-Cremades, Daniel…[et al.]. Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211745
American Medical Association (AMA)
Pérez-Cremades, Daniel& Mompeón, Ana& Vidal-Gómez, Xavier& Hermenegildo, C.& Novella, Susana. Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211745