![](/images/graphics-bg.png)
Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases
Joint Authors
Kukreja, Rakesh C.
Das, Anindita
Samidurai, Arun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-23
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Mechanistic/mammalian target of rapamycin (mTOR), an atypical serine/threonine kinase of the phosphoinositide 3-kinase- (PI3K-) related kinase family, elicits a vital role in diverse cellular processes, including cellular growth, proliferation, survival, protein synthesis, autophagy, and metabolism.
In the cardiovascular system, the mTOR signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of both physiological and pathological processes.
MicroRNAs (miRs), a class of short noncoding RNA, are an emerging intricate posttranscriptional modulator of critical gene expression for the development and maintenance of homeostasis across a wide array of tissues, including the cardiovascular system.
Over the last decade, numerous studies have revealed an interplay between miRNAs and the mTOR signaling circuit in the different cardiovascular pathophysiology, like myocardial infarction, hypertrophy, fibrosis, heart failure, arrhythmia, inflammation, and atherosclerosis.
In this review, we provide a comprehensive state of the current knowledge regarding the mechanisms of interactions between the mTOR signaling pathway and miRs.
We have also highlighted the latest advances on mTOR-targeted therapy in clinical trials and the new perspective therapeutic strategies with mTOR-targeting miRs in cardiovascular diseases.
American Psychological Association (APA)
Samidurai, Arun& Kukreja, Rakesh C.& Das, Anindita. 2018. Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1211756
Modern Language Association (MLA)
Samidurai, Arun…[et al.]. Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1211756
American Medical Association (AMA)
Samidurai, Arun& Kukreja, Rakesh C.& Das, Anindita. Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1211756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211756