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Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals
Joint Authors
Crujeiras, Ana B.
Amil, María
Casanueva, Felipe F.
Carreira, Marcos C.
Izquierdo, Andrea G.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism.
This study is aimed at evaluating the relationship between liver SIRT6 gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome.
We observed that liver-specific SIRT6 expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome.
We also observed that SIRT6 expression in the liver is positively associated with SIRT1 and GST-M2 expressions, two proteins involved in antioxidant protection pathways and inversely related to body weight and plasmatic oxidative status.
Interestingly, the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers.
These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease.
American Psychological Association (APA)
Carreira, Marcos C.& Izquierdo, Andrea G.& Amil, María& Casanueva, Felipe F.& Crujeiras, Ana B.. 2018. Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1211774
Modern Language Association (MLA)
Carreira, Marcos C.…[et al.]. Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1211774
American Medical Association (AMA)
Carreira, Marcos C.& Izquierdo, Andrea G.& Amil, María& Casanueva, Felipe F.& Crujeiras, Ana B.. Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1211774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211774