Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes
Joint Authors
Shao, Zonghong
Xing, Limin
Wang, Huaquan
Liu, Chunyan
Jiang, Huijuan
Yang, Liyan
Guo, Lifang
Cui, Ningbo
Zhang, Gaochao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by cytopenia and dysplasia.
Anemia is the most common symptom in patients with MDS.
Mitophagy and mitochondrial dysfunction might be involved in the development of MDS.
In this study, we investigated the change of mitophagy in erythroid precursors in MDS patients.
We found that NIX-mediated mitophagy was impaired in bone marrow nucleated red blood cells (NRBC) of MDS patients, associated with an increased amount of damaged mitochondria and increased ROS level which might lead to apoptosis and ineffective erythropoiesis.
The results showed that the amount of mitochondria in GlycoA+ NRBC positively correlated with the count of ring sideroblasts in bone marrow samples.
Meanwhile, the level of autophagy-associated marker LC3B in GlycoA+ NRBC had a positive correlation with hemoglobin (Hb) levels, and the amount of mitochondria in GlycoA+ NRBC had a negative correlation with Hb levels in high-risk MDS patients.
Our results indicated that mitophagy might involve the pathogenesis of anemia associated with MDS.
Autophagy might be a novel target in treatments of MDS patients.
American Psychological Association (APA)
Jiang, Huijuan& Yang, Liyan& Guo, Lifang& Cui, Ningbo& Zhang, Gaochao& Liu, Chunyan…[et al.]. 2018. Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211786
Modern Language Association (MLA)
Jiang, Huijuan…[et al.]. Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211786
American Medical Association (AMA)
Jiang, Huijuan& Yang, Liyan& Guo, Lifang& Cui, Ningbo& Zhang, Gaochao& Liu, Chunyan…[et al.]. Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211786