36H: A Novel Potent Inhibitor for Antimelanogenesis
Joint Authors
Kuo, Yueh-Hsiung
Wang, Hui-Min
Lin, Li-Ching
Kuo, Chia-Hung
Lin, Yun-Sheng
Hwang, Byeong Hee
Wang, Tina Kaiting
Chen, Chung-Yi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
N-Hydroxycinnamoylphenalkylamides (36H) exhibited both antioxidation and antityrosinase abilities.
The compound was studied for its antioxidative properties, using a 1,1-diphenyl-2-picrylhydrazul- (DPPH-) scavenging test, a ferric ion-reducing antioxidant power assay (FRAP) assessment, and a metal-chelating power assay.
The results showed that 36H had antioxidative capabilities in the DPPH-scavenging and ferric-reducing power examinations but the chelating power assay did not demonstrate antioxidative capability.
36H was also measured for tyrosinase inhibitory activity applying various species platforms, including in vitro mushroom, B16F10 mouse melanoma, and human melanocyte cells.
In terms of in vitro mushroom tyrosinase suppression, 36H restrained the melanogenesis processes.
It is assumed that 36H blocked the tyrosinase active site as a competitive inhibitor for mushroom tyrosinase, hence not decreasing the human normal melanocyte cellular viability.
A quantitative real-time polymerase chain reaction (qRT-PCR) and western blot discovered that 36H downregulated melanogenesis-related RNA and proteins, including pigment production (MITF, tyrosinase, TRP-1, and TRP-2), melanosome maturation (Rab27a), and melanosome transportation (Myo5a, MLPH and Mreg).
Overall, 36H displayed the biofunctions of antioxidation and melanin suppression, so there was a possibility for its application as a food additive or a skin-whitening agent.
American Psychological Association (APA)
Lin, Li-Ching& Chen, Chung-Yi& Kuo, Chia-Hung& Lin, Yun-Sheng& Hwang, Byeong Hee& Wang, Tina Kaiting…[et al.]. 2018. 36H: A Novel Potent Inhibitor for Antimelanogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211787
Modern Language Association (MLA)
Lin, Li-Ching…[et al.]. 36H: A Novel Potent Inhibitor for Antimelanogenesis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211787
American Medical Association (AMA)
Lin, Li-Ching& Chen, Chung-Yi& Kuo, Chia-Hung& Lin, Yun-Sheng& Hwang, Byeong Hee& Wang, Tina Kaiting…[et al.]. 36H: A Novel Potent Inhibitor for Antimelanogenesis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211787