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Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting
Joint Authors
Reano, Simone
Hirsch, Emilio
Ghigo, Alessandra
Wyart, Elisabeth
Hsu, Myriam Y.
Longo, Dario Livio
Li, Mingchuan
Porporato, Paolo Ettore
Riganti, C.
Filigheddu, Nicoletta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cancer cachexia is a devastating syndrome occurring in the majority of terminally ill cancer patients.
Notably, skeletal muscle atrophy is a consistent feature affecting the quality of life and prognosis.
To date, limited therapeutic options are available, and research in the field is hampered by the lack of satisfactory models to study the complexity of wasting in cachexia-inducing tumors, such as pancreatic cancer.
Moreover, currently used in vivo models are characterized by an explosive cachexia with a lethal wasting within few days, while pancreatic cancer patients might experience alterations long before the onset of overt wasting.
In this work, we established and characterized a slow-paced model of pancreatic cancer-induced muscle wasting that promotes efficient muscular wasting in vitro and in vivo.
Treatment with conditioned media from pancreatic cancer cells led to the induction of atrophy in vitro, while tumor-bearing mice presented a clear reduction in muscle mass and functionality.
Intriguingly, several metabolic alterations in tumor-bearing mice were identified, paving the way for therapeutic interventions with drugs targeting metabolism.
American Psychological Association (APA)
Wyart, Elisabeth& Reano, Simone& Hsu, Myriam Y.& Longo, Dario Livio& Li, Mingchuan& Hirsch, Emilio…[et al.]. 2018. Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211807
Modern Language Association (MLA)
Wyart, Elisabeth…[et al.]. Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211807
American Medical Association (AMA)
Wyart, Elisabeth& Reano, Simone& Hsu, Myriam Y.& Longo, Dario Livio& Li, Mingchuan& Hirsch, Emilio…[et al.]. Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211807