Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa
Joint Authors
Obirikorang, Christian
Agyemang-Yeboah, Francis
Aboagye, Evans
Duduyemi, Babatunde Moses
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Fewer studies have been done over the years to establish the association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSSC) within the subregions of sub-Saharan Africa, and thus this study was designed to investigate the presence of HPV in HNSCC at a tertiary hospital in Ghana, providing additional evidence on the need to explore similar studies in other subregions.
A retrospective cross-sectional study was employed to investigate the presence of the DNA of HPV genotypes in HNSCC archived tissue.
A total of 100 HNSCC cases were classified as suitable for HPV genotyping.
HPV-DNA was detected in 18% of the HNSCC cases, with 17 being HPV-16 and 1 dual infection with HPV-16 and HPV-18.
HPV was prevalent in 50% of oropharyngeal cancers, 27% of laryngeal cancers, and 23% of oral cavity cancers.
HPV E6/E7 oncogenic DNA was found in 18% of the HNSCC cases, with HPV-16 being the predominant genotype present.
The pattern of HPV association was similar to earlier reported studies, recording a higher prevalence in oropharyngeal cancers, followed by laryngeal cancers and oral cavity cancers.
American Psychological Association (APA)
Aboagye, Evans& Agyemang-Yeboah, Francis& Duduyemi, Babatunde Moses& Obirikorang, Christian. 2019. Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa. The Scientific World Journal،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1211811
Modern Language Association (MLA)
Aboagye, Evans…[et al.]. Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa. The Scientific World Journal No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1211811
American Medical Association (AMA)
Aboagye, Evans& Agyemang-Yeboah, Francis& Duduyemi, Babatunde Moses& Obirikorang, Christian. Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa. The Scientific World Journal. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1211811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211811