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Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea
Joint Authors
Gavazza, Alessandra
Rossi, Giacomo
Cerquetella, Matteo
Pengo, Graziano
Spaterna, A.
Tesei, Beniamino
Pucciarelli, Stefania
Scortichini, Luca
Sagratini, Gianni
Ricciutelli, Massimo
Marchegiani, Andrea
Vincenzetti, Silvia
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Different laboratory markers are routinely used in the diagnosis and management of gastrointestinal (GI) disease in dogs.
In the present study, starting from feces from both healthy dogs and dogs suffering from food responsive diarrhea (FRD), we tried to find proteins differently expressed in the two groups of dogs, by using a proteomic approach.
Interestingly, we found that the immunoglobulin J-chain isoform 1 (species: Canis lupus familiaris) was identified only in diseased dogs (not in healthy).
J-chain combines especially IgA monomers to IgA dimers and plays a crucial role for their secretions into mucosal interface.
Being the first study of that kind in the dog, it is only possible to hypothesize that their presence could be likely due to an increased activation of the immune system or to a mucosal damage or both in FRD patients.
Similarly, it is still impossible to assess whether this protein could be used as diagnostic/prognostic marker of GI disease; however, this study represents a promising first step toward fecal proteomics in canine GI disorders.
American Psychological Association (APA)
Cerquetella, Matteo& Rossi, Giacomo& Spaterna, A.& Tesei, Beniamino& Gavazza, Alessandra& Pengo, Graziano…[et al.]. 2019. Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea. The Scientific World Journal،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1211818
Modern Language Association (MLA)
Cerquetella, Matteo…[et al.]. Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea. The Scientific World Journal No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1211818
American Medical Association (AMA)
Cerquetella, Matteo& Rossi, Giacomo& Spaterna, A.& Tesei, Beniamino& Gavazza, Alessandra& Pengo, Graziano…[et al.]. Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea. The Scientific World Journal. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1211818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211818