Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms
Joint Authors
Douglas Melo Coutinho, Henrique
Júnior, Raimundo Gonçalves de Oliveira
Oliveira, Ana Paula de
de Lavor, Érica Martins
Fernandes, Antônio Wilton Cavalcante
de Andrade Teles, Roxana Braga
Leal, Ana Ediléia Barbosa Pereira
Gama e Silva, Mariana
Silva, Juliane Cabral
de Moura Fontes Araújo, Maria Tais
Picot, Laurent
de Menezes, Irwin Rose Alencar
Almeida, Jackson Roberto Guedes da Silva
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-23
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Inflammatory diseases result from the body’s response to tissue damage, and if the resolution is not adequate or the stimulus persists, there will be progression from acute inflammation to chronic inflammation, leading to the development of cancer and neurodegenerative and autoimmune diseases.
Due to the complexity of events that occur in inflammation associated with the adverse effects of drugs used in clinical practice, it is necessary to search for new biologically active compounds with anti-inflammatory activity.
Among natural products, essential oils (EOs) present promising results in preclinical studies, with action in the main mechanisms involved in the pathology of inflammation.
The present systematic review summarizes the pharmacological effects of EOs and their compounds in in vitro and in vivo models for inflammation.
The research was conducted in the following databases: PubMed, Scopus, BIREME, Scielo, Open Grey, and Science Direct.
Based on the inclusion criteria, 30 articles were selected and discussed in this review.
The studies listed revealed a potential activity of EOs and their compounds for the treatment of inflammatory diseases, especially in chronic inflammatory conditions, with the main mechanism involving reduction of reactive oxygen and nitrogen species associated with an elevation of antioxidant enzymes as well as the reduction of the nuclear factor kappa B (NF-κB), reducing the expression of proinflammatory cytokines.
Thus, this review suggests that EOs and their major compounds are promising tools for the treatment of chronic inflammation.
American Psychological Association (APA)
de Lavor, Érica Martins& Fernandes, Antônio Wilton Cavalcante& de Andrade Teles, Roxana Braga& Leal, Ana Ediléia Barbosa Pereira& Júnior, Raimundo Gonçalves de Oliveira& Gama e Silva, Mariana…[et al.]. 2018. Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1211826
Modern Language Association (MLA)
de Lavor, Érica Martins…[et al.]. Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1211826
American Medical Association (AMA)
de Lavor, Érica Martins& Fernandes, Antônio Wilton Cavalcante& de Andrade Teles, Roxana Braga& Leal, Ana Ediléia Barbosa Pereira& Júnior, Raimundo Gonçalves de Oliveira& Gama e Silva, Mariana…[et al.]. Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1211826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211826