Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury
Joint Authors
Mueller, Gregory P.
Bylicky, Michelle A.
Day, Regina M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Astrocytes, once believed to serve only as “glue” for the structural support of neurons, have been demonstrated to serve critical functions for the maintenance and protection of neurons, especially under conditions of acute or chronic injury.
There are at least seven distinct mechanisms by which astrocytes protect neurons from damage; these are (1) protection against glutamate toxicity, (2) protection against redox stress, (3) mediation of mitochondrial repair mechanisms, (4) protection against glucose-induced metabolic stress, (5) protection against iron toxicity, (6) modulation of the immune response in the brain, and (7) maintenance of tissue homeostasis in the presence of DNA damage.
Astrocytes support these critical functions through specialized responses to stress or toxic conditions.
The detoxifying activities of astrocytes are essential for maintenance of the microenvironment surrounding neurons and in whole tissue homeostasis.
Improved understanding of the mechanisms by which astrocytes protect the brain could lead to the development of novel targets for the development of neuroprotective strategies.
American Psychological Association (APA)
Bylicky, Michelle A.& Mueller, Gregory P.& Day, Regina M.. 2018. Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211827
Modern Language Association (MLA)
Bylicky, Michelle A.…[et al.]. Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211827
American Medical Association (AMA)
Bylicky, Michelle A.& Mueller, Gregory P.& Day, Regina M.. Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211827