Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway
Joint Authors
Cofre, Jaime
Saalfeld, Kay
Abdelhay, Eliana
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
For gastrulation to occur in human embryos, a mechanism that simultaneously regulates many different processes, such as cell differentiation, proliferation, migration, and invasion, is required to consistently and effectively create a human being during embryonic morphogenesis.
The striking similarities in the processes of cancer and gastrulation have prompted speculation regarding the developmental pathways involved in their regulation.
One of the fundamental requirements for the developmental pathways in gastrulation and cancer is the ability to respond to environmental stimuli, and it has been proposed that the Kaiso and noncanonical Wnt pathways participate in the mechanisms regulating these developmental pathways.
In particular, these pathways might also explain the notable differences in invasive capacity between cancers of endodermal and mesodermal origins and cancers of ectodermal origin.
Nevertheless, the available information indicates that cancer is an abnormal state of adult human cells in which developmental pathways are reactivated in inappropriate temporal and spatial contexts.
American Psychological Association (APA)
Cofre, Jaime& Saalfeld, Kay& Abdelhay, Eliana. 2019. Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway. The Scientific World Journal،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1211842
Modern Language Association (MLA)
Cofre, Jaime…[et al.]. Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway. The Scientific World Journal No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1211842
American Medical Association (AMA)
Cofre, Jaime& Saalfeld, Kay& Abdelhay, Eliana. Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway. The Scientific World Journal. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1211842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211842