Development of Novel Topical Cosmeceutical Formulations from Nigella sativa L. with Antimicrobial Activity against Acne-Causing Microorganisms
Joint Authors
Wijayaratne, Weerasinghe Mudiyanselage Dilip Gaya Bandara
Napagoda, Mayuri Tharanga
Nawarathne, Nirmani Wishwakala
Wijesekera, Kanchana
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Acne vulgaris occurs due to the inflammation of sebaceous follicles in the skin.
It is triggered by the activity of some bacterial species like Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis.
Acquisition of antibiotic resistance by these microorganisms and adverse effects associated with the current treatment regimens necessitate the introduction of novel therapeutic agents for acne vulgaris.
Thus, this study was undertaken to develop novel gel formulations from seeds of Nigella sativa L.
and to evaluate the antibacterial potential against some acne-causing bacterial species.
The antibacterial activity of seed extracts was initially screened against S.
aureus and P.
acnes by the agar well diffusion method.
Thereafter, topical gels were formulated incorporating the ethyl acetate extract of seeds of N.
sativa at three different concentrations.
These topical formulations were subjected to antimicrobial activity studies while the stability was evaluated over a period of 30 days.
All three formulations were capable of inhibiting the growth of S.
aureus and P.
acnes, with the highest antibacterial activity in the formulation comprising 15% of the seed extract.
Interestingly, the antibacterial potency of this formulation against S.
aureus surpassed the commercial synthetic product used as the positive control.
Moreover, any alteration in color, odor, homogeneity, washability, consistency, and pH was not observed while the antibacterial potency was also retained during the storage period.
The potent antibacterial activity in topical gel formulations developed from the ethyl acetate extract of N.
sativa signposts their suitability as alternatives to existing antiacne agents in the management of acne vulgaris.
American Psychological Association (APA)
Nawarathne, Nirmani Wishwakala& Wijesekera, Kanchana& Wijayaratne, Weerasinghe Mudiyanselage Dilip Gaya Bandara& Napagoda, Mayuri Tharanga. 2019. Development of Novel Topical Cosmeceutical Formulations from Nigella sativa L. with Antimicrobial Activity against Acne-Causing Microorganisms. The Scientific World Journal،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1211865
Modern Language Association (MLA)
Nawarathne, Nirmani Wishwakala…[et al.]. Development of Novel Topical Cosmeceutical Formulations from Nigella sativa L. with Antimicrobial Activity against Acne-Causing Microorganisms. The Scientific World Journal No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1211865
American Medical Association (AMA)
Nawarathne, Nirmani Wishwakala& Wijesekera, Kanchana& Wijayaratne, Weerasinghe Mudiyanselage Dilip Gaya Bandara& Napagoda, Mayuri Tharanga. Development of Novel Topical Cosmeceutical Formulations from Nigella sativa L. with Antimicrobial Activity against Acne-Causing Microorganisms. The Scientific World Journal. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1211865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211865