High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway
Joint Authors
Zhou, Mengtao
Chen, Bi-Cheng
Li, Ding
Zhu, Xiandong
Xiang, Yukai
Xu, Xiangxiang
Luo, Jiao
Fang, Dazhang
Ni, Fubiao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aberrant glucose metabolism of diabetes mellitus or hyperglycemia stimulates pancreatic tumorigenesis and progression.
Hyperglycemic environment can increase the ROS level of tumors, but the role of upregulation of ROS levels in pancreatic cancer (PC) still remains controversial.
Here, the same as other reports, we demonstrate that high glucose promoted pancreatic cancer cell growth and resulted in an increase in the level of ROS.
However, it is interesting that the phosphorylation of JNK was reduced.
When treating PC cells with N-acetyl-L-cysteine (NAC), the intracellular ROS generation is repressed, but the expression of phosphorylation of JNK and c-Jun increased.
Moreover, the JNK inhibitor SP600125 significantly promoted cell proliferation and suppressed cell apoptosis of pancreatic cancer cells under high glucose conditions.
Collectively, high levels of ROS induced by high glucose conditions stimulated the proliferation of pancreatic cancer cells, and it may be achieved by inactivating the JNK pathway.
American Psychological Association (APA)
Luo, Jiao& Xiang, Yukai& Xu, Xiangxiang& Fang, Dazhang& Li, Ding& Ni, Fubiao…[et al.]. 2018. High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211875
Modern Language Association (MLA)
Luo, Jiao…[et al.]. High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211875
American Medical Association (AMA)
Luo, Jiao& Xiang, Yukai& Xu, Xiangxiang& Fang, Dazhang& Li, Ding& Ni, Fubiao…[et al.]. High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211875