Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E
Joint Authors
Saadeldin, Islam M.
Swelum, Ayman Abdel-Aziz
Abdelazim, Aaser M.
Afifi, Mohamed M.
Alkaladi, Ali
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined.
Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium).
Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; the 2nd and 3rd groups were exposed to 1 and 2 mg/L of ZnONPs, respectively; and the 4th and 5th group were exposed to 1 and 2 mg/L of ZnONPs and treated with a (500 mg/kg diet) mixture of vitamin C and E mixture (250 mg/kg diet of each).
Muscles were collected on the 7th and 15th day of treatments.
Muscle malondialdehyde, reduced glutathione levels, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GR), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activities were measured after treatments.
Relative quantification of SOD, CAT, GR, GPx, and GST mRNA transcripts was detected in the muscles.
Results showed that MDA and GSH concentration; SOD, CAT, GR, GPx, and GST activities; and mRNA expression were significantly decreased in groups exposed to ZnONPs.
Vitamins C and E significantly ameliorated the toxic effects of ZnONPs.
In conclusion, vitamins C and E have the ability to ameliorate ZnONP oxidative stress toxicity in Nile tilapia.
American Psychological Association (APA)
Abdelazim, Aaser M.& Saadeldin, Islam M.& Swelum, Ayman Abdel-Aziz& Afifi, Mohamed M.& Alkaladi, Ali. 2018. Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211887
Modern Language Association (MLA)
Abdelazim, Aaser M.…[et al.]. Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211887
American Medical Association (AMA)
Abdelazim, Aaser M.& Saadeldin, Islam M.& Swelum, Ayman Abdel-Aziz& Afifi, Mohamed M.& Alkaladi, Ali. Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211887