Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis
Joint Authors
McCarthy, David J.
Diaz, Anthony
Sheinberg, Dallas L.
Snelling, Brian
Luther, Evan M.
Chen, Stephanie H.
Yavagal, Dileep R.
Peterson, Eric C.
Starke, Robert M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Mechanical thrombectomy (MT) has become the standard treatment for large vessel occlusion (LVO) in acute ischemic stroke (AIS).
Few studies have investigated long-term outcomes for AIS treated with MT.
Therefore, a pooled meta-analysis using data from randomized clinical trials (RCT) was performed to assess for long-term clinical outcomes.
A systematic literature search was conducted on 27 September 2017, by searching the English literature in the Cochrane Library, MEDLINE, and Embase for RCTs investigating long-term outcomes (greater than standard 3-month timepoint) of endovascular intervention versus medical management for patients with AIS.
The study was carried out according to PRISMA guidelines and random effects analysis was carried out to account for heterogeneity.
Three trials were included: IMS III, MR CLEAN, and REVASCAT, comprising a total of 1,362 patients.
Long-term clinical outcomes were available for 1-year follow-up in IMS III and REVASCAT and at 2 years in MR CLEAN.
Functional independence at long-term follow-up favored endovascular stroke intervention (OR 1.51; p = 0.02).
When stratified by LVO inclusion criteria, greater endovascular functional independence benefits were observed (OR 1.85; p = 0.0005).
There was a significant difference between the 2 arms in favor of endovascular therapy for the quality of life at long-term follow-up (mean difference 0.11; p = 0.0002).
No difference in mortality at long-term follow-up was observed (OR 0.82; p = 0.12).
We conclude that endovascular therapy results in favorable outcomes at long-term follow-up for patients with acute ischemic stroke compared to standard medical treatment alone and that the 90-day timepoint offers a fair representation of the long-term outcomes.
American Psychological Association (APA)
McCarthy, David J.& Diaz, Anthony& Sheinberg, Dallas L.& Snelling, Brian& Luther, Evan M.& Chen, Stephanie H.…[et al.]. 2019. Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis. The Scientific World Journal،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1211894
Modern Language Association (MLA)
McCarthy, David J.…[et al.]. Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis. The Scientific World Journal No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1211894
American Medical Association (AMA)
McCarthy, David J.& Diaz, Anthony& Sheinberg, Dallas L.& Snelling, Brian& Luther, Evan M.& Chen, Stephanie H.…[et al.]. Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis. The Scientific World Journal. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1211894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211894