Apigenin Protects the Brain against IschemiaReperfusion Injury via Caveolin-1VEGF In Vitro and In Vivo
Joint Authors
Chen, Xiang
Pang, Qiongyi
Zhao, Yun
Zhao, Kaiyi
Zhai, Qiongxiang
Tu, Fengxia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Apigenin is a natural flavonoid found in several dietary plant foods as vegetables and fruits.
To investigate potential anti-ischemia/reperfusion injury properties of apigenin in vitro, cell proliferation assay, tube formation, cell migration, apoptosis, and autophagy were performed in human brain microvascular endothelial cells (HBMVECs) after oxygen-glucose deprivation/reoxygenation (OGD/R).
The effect of apigenin was also explored in rats after middle cerebral artery occlusion/reperfusion (MCAO/R) via neurobehavioral scores, pathological examination, and measurement of markers involved in ischemia/reperfusion injury.
Data in vitro indicated that apigenin could prompt cell proliferation, tube formation, and cell migration while inhibiting apoptosis and autophagy by affecting Caveolin-1/VEGF, Bcl-2, Caspase-3, Beclin-1, and mTOR expression.
Results in vivo showed that apigenin significantly reduced neurobehavioral scores and volume of cerebral infarction while prompting vascular endothelial cell proliferation by upregulating VEGFR2/CD34 double-labeling endothelial progenitor cell (EPC) number and affecting Caveolin-1, VEGF, and eNOS expression in brain tissue of MCAO/R rats.
All the data suggested that apigenin may be protective for the brain against ischemia/reperfusion injury by alleviating apoptosis and autophagy, promoting cell proliferation in HBMVECs of OGD/R, and attenuating brain damage and improved neurological function in rats of MCAO/R through the Caveolin-1/VEGF pathway.
American Psychological Association (APA)
Pang, Qiongyi& Zhao, Yun& Chen, Xiang& Zhao, Kaiyi& Zhai, Qiongxiang& Tu, Fengxia. 2018. Apigenin Protects the Brain against IschemiaReperfusion Injury via Caveolin-1VEGF In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211928
Modern Language Association (MLA)
Pang, Qiongyi…[et al.]. Apigenin Protects the Brain against IschemiaReperfusion Injury via Caveolin-1VEGF In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211928
American Medical Association (AMA)
Pang, Qiongyi& Zhao, Yun& Chen, Xiang& Zhao, Kaiyi& Zhai, Qiongxiang& Tu, Fengxia. Apigenin Protects the Brain against IschemiaReperfusion Injury via Caveolin-1VEGF In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211928