![](/images/graphics-bg.png)
Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability
Joint Authors
Dhillon, V. S.
Silva, Juliana da
Kahl, Vivian F. Silva
Fenech, Michael
de Souza, Melissa Rosa
da Silva, Fabiane Nitzke
Marroni, Norma Anair Possa
Nunes, Emilene Arusievicz
Cerchiaro, Giselle
Pedron, Tatiana
Batista, Bruno Lemos
Cappetta, Mónica
Mártinez-López, Wilner
Simon, Daniel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pesticides used at tobacco fields are associated with genomic instability, which is proposed to be sensitive to nutritional intake and may also induce epigenetic changes.
We evaluated the effect of dietary intake and genetic susceptibility polymorphisms in MTHFR (rs1801133) and TERT (rs2736100) genes on genomic and epigenetic instability in tobacco farmers.
Farmers, when compared to a nonexposed group, showed increased levels of different parameters of DNA damage (micronuclei, nucleoplasmic bridges, and nuclear buds), evaluated by cytokinesis-block micronucleus cytome assay.
Telomere length (TL) measured by quantitative PCR was shorter in exposed individuals.
Global DNA methylation was significantly decreased in tobacco farmers.
The exposed group had lower dietary intake of fiber, but an increase in cholesterol; vitamins such as B6, B12, and C; β-carotene; and α-retinol.
Several trace and ultratrace elements were found higher in farmers than in nonfarmers.
The MTHFR CT/TT genotype influenced nucleoplasmic bridges, nuclear buds, and TL in the exposed group, whereas TERT GT/TT only affected micronucleus frequency.
We observed a positive correlation of TL and lipids and an inverse correlation of TL and fibers.
The present data suggest an important role of dietary intake and subjects’ genetic susceptibility to xenobiotics-induced damages and epigenetic alterations in tobacco farmers occupationally exposed to mixtures of pesticides.
American Psychological Association (APA)
Kahl, Vivian F. Silva& Dhillon, V. S.& Fenech, Michael& de Souza, Melissa Rosa& da Silva, Fabiane Nitzke& Marroni, Norma Anair Possa…[et al.]. 2018. Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211930
Modern Language Association (MLA)
Kahl, Vivian F. Silva…[et al.]. Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211930
American Medical Association (AMA)
Kahl, Vivian F. Silva& Dhillon, V. S.& Fenech, Michael& de Souza, Melissa Rosa& da Silva, Fabiane Nitzke& Marroni, Norma Anair Possa…[et al.]. Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211930