Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats
Joint Authors
Bietiger, William
Marchioni, Eric
Jeandidier, Nathalie
Maillard, Elisa
Sigrist, Séverine
Peronet, C.
Mura, C.
Dal, Stéphanie
Van der Werf, Remmelt
Walter, Catherine
Seyfritz, Elodie
Legrandois, Julie
Werner, Dalal
Ennahar, Said
Digel, Fabien
Pinget, Michel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Aims.
Oxidative stress (OS) plays a major role in type 2 diabetes and its vascular and hepatic complications, and novel therapeutic approaches include natural antioxidants.
Our previous chemical and biological studies demonstrated the antioxidant activities of red cabbage (RC), and here, we aimed to determine the in vivo effects of 2-month long RC consumption using a high-fat/high-fructose model of diabetic rats.
Results.
This vegetable, associated with lifestyle measurement, was shown to decrease OS and increase vascular endothelial NO synthase expression, ensuring vascular homeostasis.
In the liver, RC consumption decreased OS by inhibiting p22phox expression and Nrf2 degradation and increasing catalase activity.
It inhibited the activation of SREBP (1c, 2), ChREBP, NF-κB, ERK1/2, PPARγ, and GS and SIRT1 decrease, as observed in diabetic rats.
Conclusion/innovation.
RC consumption led to metabolic profile improvement, together with hepatic function improvements.
Although lifestyle changes are not sufficient to prevent diabetic complications, enrichment with RC avoids progression hepatic complications.
This antioxidant strategy using RC does not only able to increase antioxidant defense, such as classical antioxidant, but also able to assure a metabolic and energetic balance to reverse complications.
Whereas traditional medical therapy failed to reverse NASH in diabetic patients, consumption of RC should be a natural therapy to treat it.
American Psychological Association (APA)
Dal, Stéphanie& Van der Werf, Remmelt& Walter, Catherine& Bietiger, William& Seyfritz, Elodie& Mura, C.…[et al.]. 2018. Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211932
Modern Language Association (MLA)
Dal, Stéphanie…[et al.]. Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211932
American Medical Association (AMA)
Dal, Stéphanie& Van der Werf, Remmelt& Walter, Catherine& Bietiger, William& Seyfritz, Elodie& Mura, C.…[et al.]. Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211932