Modulating Metabolism to Improve Cancer-Induced Muscle Wasting
Joint Authors
Costelli, P.
Penna, Fabio
Ballarò, Riccardo
Beltrá, Marc
De Lucia, Serena
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Muscle wasting is one of the main features of cancer cachexia, a multifactorial syndrome frequently occurring in oncologic patients.
The onset of cachexia is associated with reduced tolerance and response to antineoplastic treatments, eventually leading to clinical conditions that are not compatible with survival.
Among the mechanisms underlying cachexia, protein and energy dysmetabolism play a major role.
In this regard, several potential treatments have been proposed, mainly on the basis of promising results obtained in preclinical models.
However, at present, no treatment yet reached validation to be used in the clinical practice, although several drugs are currently tested in clinical trials for their ability to improve muscle metabolism in cancer patients.
Along this line, the results obtained in both experimental and clinical studies clearly show that cachexia can be effectively approached by a multidirectional strategy targeting nutrition, inflammation, catabolism, and inactivity at the same time.
In the present study, approaches aimed to modulate muscle metabolism in cachexia will be reviewed.
American Psychological Association (APA)
Penna, Fabio& Ballarò, Riccardo& Beltrá, Marc& De Lucia, Serena& Costelli, P.. 2018. Modulating Metabolism to Improve Cancer-Induced Muscle Wasting. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211947
Modern Language Association (MLA)
Penna, Fabio…[et al.]. Modulating Metabolism to Improve Cancer-Induced Muscle Wasting. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211947
American Medical Association (AMA)
Penna, Fabio& Ballarò, Riccardo& Beltrá, Marc& De Lucia, Serena& Costelli, P.. Modulating Metabolism to Improve Cancer-Induced Muscle Wasting. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211947