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SIRT3: A New Regulator of Cardiovascular Diseases
Joint Authors
Liu, Bin
Liu, Ning
Sun, Wei
Yan, Youyou
Liu, Caixia
Chen, Qiuhui
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in mitochondrial function contribute largely to the occurrence of CVDs.
Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD+-dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle, oxidative stress, and apoptosis by reversible protein lysine deacetylation.
SIRT3 regulates glucose and lipid metabolism and maintains myocardial ATP levels, which protects the heart from metabolic disturbances.
SIRT3 can also protect cardiomyocytes from oxidative stress-mediated cell damage and block the development of cardiac hypertrophy.
Recent reports show that SIRT3 is involved in the protection of several heart diseases.
This review discusses the progress in SIRT3-related research and the role of SIRT3 in the prevention and treatment of CVDs.
American Psychological Association (APA)
Sun, Wei& Liu, Caixia& Chen, Qiuhui& Liu, Ning& Yan, Youyou& Liu, Bin. 2018. SIRT3: A New Regulator of Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211967
Modern Language Association (MLA)
Sun, Wei…[et al.]. SIRT3: A New Regulator of Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211967
American Medical Association (AMA)
Sun, Wei& Liu, Caixia& Chen, Qiuhui& Liu, Ning& Yan, Youyou& Liu, Bin. SIRT3: A New Regulator of Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211967