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Oxidative Stress and Necrotizing Enterocolitis: Pathogenetic Mechanisms, Opportunities for Intervention, and Role of Human Milk
Joint Authors
Faldella, Giacomo
Aceti, Arianna
Beghetti, Isadora
Corvaglia, Luigi
Martini, Silvia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This review will examine the role of oxidative stress (OS) in the pathogenesis of necrotizing enterocolitis (NEC) and explore potential preventive and therapeutic antioxidant strategies.
Preterm infants are particularly exposed to OS as a result of several perinatal stimuli and constitutive defective antioxidant defenses.
For this reason, OS damage represents a contributing factor to several complications of prematurity, including necrotizing enterocolitis (NEC).
Being NEC a multifactorial disease, OS may act as downstream component of the pathogenetic cascade.
To counteract OS in preterm infants with NEC, several antioxidant strategies have been proposed and different antioxidant compounds have been experimented.
It is well known that human milk (HM) is an important source of antioxidants.
At the same time, the role of an exclusive HM diet is well recognized in the prevention of NEC.
However, donor HM (DHM) processing may impair antioxidant properties.
As DHM is becoming a common nutritional intervention for high risk PI, the antioxidant status of preterm and DHM and potential ways to preserve its antioxidant capacity may merit further investigation.
American Psychological Association (APA)
Aceti, Arianna& Beghetti, Isadora& Martini, Silvia& Faldella, Giacomo& Corvaglia, Luigi. 2018. Oxidative Stress and Necrotizing Enterocolitis: Pathogenetic Mechanisms, Opportunities for Intervention, and Role of Human Milk. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1211973
Modern Language Association (MLA)
Aceti, Arianna…[et al.]. Oxidative Stress and Necrotizing Enterocolitis: Pathogenetic Mechanisms, Opportunities for Intervention, and Role of Human Milk. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1211973
American Medical Association (AMA)
Aceti, Arianna& Beghetti, Isadora& Martini, Silvia& Faldella, Giacomo& Corvaglia, Luigi. Oxidative Stress and Necrotizing Enterocolitis: Pathogenetic Mechanisms, Opportunities for Intervention, and Role of Human Milk. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1211973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211973