The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations
Joint Authors
Di Mauro, Antonio
Laforgia, Nicola
Capozza, Manuela
De Cosmo, Lucrezia
Resta, Nicoletta
Favia Guarnieri, Giovanna
Varvara, Dora
Panza, Raffaella
Baldassarre, Maria Elisabetta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Congenital anomalies are significant causes of mortality and morbidity in infancy and childhood.
Embryogenesis requires specific signaling pathways to regulate cell proliferation and differentiation.
These signaling pathways are sensitive to endogenous and exogenous agents able to produce several structural changes of the developing fetus.
Oxidative stress, due to an imbalance between the production of reactive oxygen species and antioxidant defenses, disrupts signaling pathways with a causative role in birth defects.
This review provides a basis for understanding the role of oxidative stress in the pathomechanism of congenital malformations, discussing the mechanisms related to some congenital malformations.
New insights in the knowledge of pathomechanism of oxidative stress-related congenital malformations, according to experimental and human studies, represent the basis of possible clinical applications in screening, prevention, and therapies.
American Psychological Association (APA)
Laforgia, Nicola& Di Mauro, Antonio& Favia Guarnieri, Giovanna& Varvara, Dora& De Cosmo, Lucrezia& Panza, Raffaella…[et al.]. 2018. The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211974
Modern Language Association (MLA)
Laforgia, Nicola…[et al.]. The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211974
American Medical Association (AMA)
Laforgia, Nicola& Di Mauro, Antonio& Favia Guarnieri, Giovanna& Varvara, Dora& De Cosmo, Lucrezia& Panza, Raffaella…[et al.]. The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211974