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An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
Joint Authors
Fernández, Adelaida Esteban
Tiano, Simoni
Huang, Jing
Floyd, Elizabeth
Poulev, Alexander
Pasinetti, Giulio Maria
Wang, Jun
Ribnicky, David M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Stress-induced peripheral inflammation contributes to depression-like behaviors in both human and experimental models.
PMI 5011, a botanical extract of Artemisia dracunculus L., was previously shown to have multiple bioactivities, including anti-inflammatory activity.
In this work, using a repeated social defeat stress (RSDS) model of depression, we demonstrate that oral administration of the botanical extract PMI 5011 promotes resilience to RSDS-mediated depression-like phenotypes.
We also show that the behavioral improvements are associated with attenuation of stress-mediated induction of inflammatory cytokines in the periphery and alteration of synaptic plasticity in the nucleus accumbens (NAc).
Our studies provide experimental evidence that botanical extracts such as PMI 5011, which target pathological mechanisms (i.e., peripheral inflammation) not addressed by currently available antidepressants, could be further developed as novel therapeutics for the treatment of stress disorders and anxiety in humans.
American Psychological Association (APA)
Wang, Jun& Fernández, Adelaida Esteban& Tiano, Simoni& Huang, Jing& Floyd, Elizabeth& Poulev, Alexander…[et al.]. 2018. An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211986
Modern Language Association (MLA)
Wang, Jun…[et al.]. An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211986
American Medical Association (AMA)
Wang, Jun& Fernández, Adelaida Esteban& Tiano, Simoni& Huang, Jing& Floyd, Elizabeth& Poulev, Alexander…[et al.]. An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211986