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Solid Lipid Nanoparticles of Myricitrin Have Antioxidant and Antidiabetic Effects on Streptozotocin-Nicotinamide-Induced Diabetic Model and Myotube Cell of Male Mouse
Joint Authors
Kouchak, Maryam
Oroojan, Ali Akbar
Ahangarpour, Akram
Khorsandi, Layasadat
Badavi, Mohammad
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) may occur via oxidative stress.
Myricitrin is a plant-derived antioxidant, and its solid lipid nanoparticle (SLN) may be more potent.
Hence, the present study was conducted to evaluate the effects of myricitrin SLN on streptozotocin-nicotinamide- (STZ-NA-) induced T2DM of the mouse and hyperglycemic myotube.
In this experimental study, cold homogenization method was used to prepare SLN.
Then, 120 adult male NMRI mice were divided into 7 groups: control, vehicle, diabetes (received STZ 65 mg/kg 15 min after injected NA 120 mg/kg), diabetes + SLN containing myricitrin 1, 3, and 10 mg/kg, and diabetes + metformin.
For in vitro study, myoblast (C2C12) cell line was cultured and divided into 6 groups (n=3): control, hyperglycemia, hyperglycemia + SLN containing myricitrin 1, 3, and, 10 μM, and hyperglycemia + metformin.
After the last nanoparticle treatment, plasma samples, pancreas and muscle tissues, and myotubes were taken for experimental assessments.
Diabetes increased lipid peroxidation and reduced antioxidant defense along with the hyperglycemia, insulin resistance, and pancreas apoptosis.
Hyperglycemia induced oxidative stress, antioxidant impairment, and cellular apoptosis.
Myricitrin SLN improved diabetes and hyperglycemia complications in the in vivo and in vitro studies.
Therefore, SLN of myricitrin showed antioxidant, antidiabetic, and antiapoptotic effects in the mouse and myotube cells.
American Psychological Association (APA)
Ahangarpour, Akram& Oroojan, Ali Akbar& Khorsandi, Layasadat& Kouchak, Maryam& Badavi, Mohammad. 2018. Solid Lipid Nanoparticles of Myricitrin Have Antioxidant and Antidiabetic Effects on Streptozotocin-Nicotinamide-Induced Diabetic Model and Myotube Cell of Male Mouse. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1212006
Modern Language Association (MLA)
Ahangarpour, Akram…[et al.]. Solid Lipid Nanoparticles of Myricitrin Have Antioxidant and Antidiabetic Effects on Streptozotocin-Nicotinamide-Induced Diabetic Model and Myotube Cell of Male Mouse. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1212006
American Medical Association (AMA)
Ahangarpour, Akram& Oroojan, Ali Akbar& Khorsandi, Layasadat& Kouchak, Maryam& Badavi, Mohammad. Solid Lipid Nanoparticles of Myricitrin Have Antioxidant and Antidiabetic Effects on Streptozotocin-Nicotinamide-Induced Diabetic Model and Myotube Cell of Male Mouse. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1212006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212006