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Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response
Joint Authors
Li, Guo-Hui
Li, Yan-Ru
Lou, Hong-Xiang
Shen, Tao
Sun, Lin
Li, Lin
Liu, Yue
Kong, De-Gang
Wang, Shu-Qi
Ren, Dong-Mei
Wang, Xiao-Ning
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Oxidative stress and inflammation undoubtedly contribute to the pathogenesis of many human diseases.
The nuclear transcription factor erythroid 2-related factor (Nrf2) and the nuclear factor κB (NF-κB) play central roles in regulation of oxidative stress and inflammation and thus are targets for developing agents against oxidative stress- and inflammation-related diseases.
Our previous study indicated that the EtOH extract of Litsea garrettii protected human bronchial epithelial cells against oxidative insult via the activation of Nrf2.
In the present study, a systemic phytochemical investigation of L.
garrettii led to the isolation of twenty-one chemical ingredients, which were further evaluated for their inhibitions on oxidative stress and inflammation using NAD(P)H:quinone reductase (QR) assay and nitric oxide (NO) production assay.
Of these ingredients, 3-methoxy-5-pentyl-phenol (MPP, 5) was identified as an Nrf2 activator and an NF-κB inhibitor.
Further studies demonstrated the following: (i) MPP upregulated the protein levels of Nrf2, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase regulatory subunit (GCLM); enhanced the nuclear translocation and stabilization of Nrf2; and inhibited arsenic [As(III)]-induced oxidative insult in normal human lung epithelial Beas-2B cells.
And (ii) MPP suppressed the nuclear translocation of NF-κB p65 subunit; inhibited the lipopolysaccharide- (LPS-) stimulated increases of NF-κB p65 subunit, COX-2, iNOS, TNF-α, and IL-1β; and blocked the LPS-induced biodegrade of IκB-α in RAW 264.7 murine macrophages.
Taken together, MPP displayed potential preventive effects against inflammation- and oxidative stress-related diseases.
American Psychological Association (APA)
Li, Yan-Ru& Li, Guo-Hui& Sun, Lin& Li, Lin& Liu, Yue& Kong, De-Gang…[et al.]. 2018. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212047
Modern Language Association (MLA)
Li, Yan-Ru…[et al.]. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212047
American Medical Association (AMA)
Li, Yan-Ru& Li, Guo-Hui& Sun, Lin& Li, Lin& Liu, Yue& Kong, De-Gang…[et al.]. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212047