Physiological Hypoxia Enhances Stemness Preservation, Proliferation, and Bidifferentiation of Induced Hepatic Stem Cells
Joint Authors
Jun, Xiong
Zhao, Jian
Zhi, Xiaosong
Wang, Mengchao
Zhang, Hongxia
Huang, Gang
Zi, Xiaoyuan
Hu, Yi-Ping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Induced hepatic stem cells (iHepSCs) have great potential as donors for liver cell therapy due to their self-renewal and bipotential differentiation properties.
However, the efficiency of bidifferentiation and repopulation efficiency of iHepSCs is relatively low.
Recent evidence shows that physiological hypoxia, a vital factor within stem cell “niche” microenvironment, plays key roles in regulating tissue stem cell biological behaviors including proliferation and differentiation.
In this study, we found that physiological hypoxia (10% O2) enhanced the stemness properties and promoted the proliferation ability of iHepSCs by accelerating G1/S transition via p53-p21 signaling pathway.
In addition, short-term hypoxia preconditioning improved the efficiency of hepatic differentiation of iHepSCs, and long-term hypoxia promoted cholangiocytic differentiation but inhibited hepatic differentiation of iHepSCs.
These results demonstrated the potential effects of hypoxia on stemness preservation, proliferation, and bidifferentiation of iHepSCs and promising perspective to explore appropriate culture conditions for therapeutic stem cells.
American Psychological Association (APA)
Zhi, Xiaosong& Jun, Xiong& Wang, Mengchao& Zhang, Hongxia& Huang, Gang& Zhao, Jian…[et al.]. 2018. Physiological Hypoxia Enhances Stemness Preservation, Proliferation, and Bidifferentiation of Induced Hepatic Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212049
Modern Language Association (MLA)
Zhi, Xiaosong…[et al.]. Physiological Hypoxia Enhances Stemness Preservation, Proliferation, and Bidifferentiation of Induced Hepatic Stem Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212049
American Medical Association (AMA)
Zhi, Xiaosong& Jun, Xiong& Wang, Mengchao& Zhang, Hongxia& Huang, Gang& Zhao, Jian…[et al.]. Physiological Hypoxia Enhances Stemness Preservation, Proliferation, and Bidifferentiation of Induced Hepatic Stem Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212049