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Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes
Joint Authors
Wang, Zhenhua
Li, Gang
Ma, Cheng-jun
Wang, Honglun
Suo, Yourui
Luan, Guangxiang
He, Yanfeng
Tie, Fangfang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fenugreek (Trigonella foenum-graecum L.) is a well-known annual plant that is widely distributed worldwide and has possessed obvious hypoglycemic and hypercholesterolemia characteristics.
In our previous study, three polyphenol stilbenes were separated from fenugreek seeds.
Here, we investigated the effect of polyphenol stilbenes on adipogenesis and insulin resistance in 3T3-L1 adipocytes.
Oil Red O staining and triglyceride assays showed that polyphenol stilbenes differently reduced lipid accumulation by suppressing the expression of adipocyte-specific proteins.
In addition, polyphenol stilbenes improved the uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) by promoting the phosphorylation of protein kinase B (AKT) and AMP-activated protein kinase (AMPK).
In present studies, it was found that polyphenol stilbenes had the ability to scavenge reactive oxygen species (ROS).
Results from adenosine triphosphate (ATP) production and mitochondrial membrane potentials suggested that mitochondria play a critical role in insulin resistance and related signaling activation, such as AKT and AMPK.
Rhaponticin, one of the stilbenes from fenugreek, had the strongest activity among the three compounds in vitro.
Future studies will focus on mitochondrial biogenesis and function.
American Psychological Association (APA)
Li, Gang& Luan, Guangxiang& He, Yanfeng& Tie, Fangfang& Wang, Zhenhua& Suo, Yourui…[et al.]. 2018. Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212056
Modern Language Association (MLA)
Li, Gang…[et al.]. Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212056
American Medical Association (AMA)
Li, Gang& Luan, Guangxiang& He, Yanfeng& Tie, Fangfang& Wang, Zhenhua& Suo, Yourui…[et al.]. Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212056