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Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats
Joint Authors
Maruyama, Toru
Otagiri, Masaki
Uchimura, Kohei
Muraya, Nanako
Kadowaki, Daisuke
Miyamura, Shigeyuki
Kitamura, Kenichiro
Narita, Yuki
Miyamoto, Yohei
Chuang, Victor Tuan Giam
Taguchi, Kazuaki
Hirata, Sumio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD).
It is therefore important to reduce oxidative stress to treat hyperuricemia.
We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect in vitro.
The antioxidant effects of benzbromarone were evaluated in vivo via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension.
Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers.
Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration.
These results suggest that benzbromarone has a direct antioxidant effect in vivo and great potential to prevent CVD and CKD.
American Psychological Association (APA)
Muraya, Nanako& Kadowaki, Daisuke& Miyamura, Shigeyuki& Kitamura, Kenichiro& Uchimura, Kohei& Narita, Yuki…[et al.]. 2018. Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212060
Modern Language Association (MLA)
Muraya, Nanako…[et al.]. Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212060
American Medical Association (AMA)
Muraya, Nanako& Kadowaki, Daisuke& Miyamura, Shigeyuki& Kitamura, Kenichiro& Uchimura, Kohei& Narita, Yuki…[et al.]. Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212060