Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism
Joint Authors
Cui, Wei
Luo, Yongting
Xu, Wenyi
Li, Guannan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In all eukaryotes, the mechanistic target of rapamycin (mTOR) signaling emerges as a master regulator of homeostasis, which integrates environmental inputs, including nutrients, energy, and growth factors, to regulate many fundamental cellular processes such as cell growth and metabolism.
mTOR signaling functions through two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which correspond to two major branches of signal output.
While mTORC1 is well characterized for its structure, regulation, and function in the last decade, information of mTORC2 signaling is only rapidly expanding in recent years, from structural biology, signaling network, to functional impact.
Here we review the recent advances in many aspects of the mTORC2 signaling, with particular focus on its involvement in the control of cell metabolism and its physiological implications in metabolic diseases and aging.
American Psychological Association (APA)
Luo, Yongting& Xu, Wenyi& Li, Guannan& Cui, Wei. 2018. Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212088
Modern Language Association (MLA)
Luo, Yongting…[et al.]. Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212088
American Medical Association (AMA)
Luo, Yongting& Xu, Wenyi& Li, Guannan& Cui, Wei. Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212088