Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD
Joint Authors
Dudzińska, Ewa
Gryzinska, Magdalena
Kocki, Janusz
Gil-Kulik, Paulina
Ognik, Katarzyna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxidative stress plays an important role in IBD because chronic intestinal inflammation is associated with the overproduction of reactive oxygen species (ROS) leading to oxidative stress, which has been implicated in IBD.
Many lines of evidence suggest that IBD is associated with an imbalance between ROS and antioxidant activity which generates oxidative stress as the result of either ROS overproduction or a decrease in antioxidant activity.
Our study was to evaluate the influence of oxidative stress and antioxidants on the course of the disease and treatment of IBD patients.
Our results show that an increase of LOOH levels positively correlates with an increase in MDA levels; therefore, MDA may be a marker indicating lipid peroxidation.
Also, being the decomposition product of oxidation processes, MDA may be applied as a useful biomarker for identifying the effect of endogenous oxidative stress in Crohn’s disease patients.
The anti-inflammatory efficacy of AZA drugs may be the result of a reduction of the amount of lipid peroxides in the intestinal mucosa cells in CD patients and facilitate mucosal healing.
American Psychological Association (APA)
Dudzińska, Ewa& Gryzinska, Magdalena& Ognik, Katarzyna& Gil-Kulik, Paulina& Kocki, Janusz. 2018. Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212129
Modern Language Association (MLA)
Dudzińska, Ewa…[et al.]. Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212129
American Medical Association (AMA)
Dudzińska, Ewa& Gryzinska, Magdalena& Ognik, Katarzyna& Gil-Kulik, Paulina& Kocki, Janusz. Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212129