The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner
Joint Authors
Vitale, Salvatore Giovanni
Valenti, Gaetano
Sapia, Fabrizio
La Rosa, Valentina Lucia
Rossetti, Diego
Vitagliano, Amerigo
Sarpietro, Giuseppe
Capriglione, Stella
Peterlunger, Isabel
Angioli, Roberto
Lopez, Salvatore
Zito, Gabriella
Noventa, Marco
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction.
It is one of the most widespread gynecological diseases with a 10–15% prevalence in the general female population, rising up to 30–45% in patients with infertility.
Although it was first described in 1860, its etiology and pathogenesis are still unclear.
It is now accepted that inflammation plays a central role in the development and progression of endometriosis.
In particular, it is marked by an inflammatory process associated with the overproduction of an array of inflammatory mediators such as prostaglandins, metalloproteinases, cytokines, and chemokines.
In addition, the growth and adhesion of endometrial cells in the peritoneal cavity due to reactive oxygen species (ROS) and free radicals lead to disease onset, its ensuing symptoms—among which pain and infertility.
The aim of our review is to evaluate the role of oxidative stress and ROS in the pathogenesis of endometriosis and the efficacy of antioxidant therapy in the treatment and mitigation of its symptoms.
American Psychological Association (APA)
Vitale, Salvatore Giovanni& Capriglione, Stella& Peterlunger, Isabel& La Rosa, Valentina Lucia& Vitagliano, Amerigo& Noventa, Marco…[et al.]. 2018. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212131
Modern Language Association (MLA)
Vitale, Salvatore Giovanni…[et al.]. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212131
American Medical Association (AMA)
Vitale, Salvatore Giovanni& Capriglione, Stella& Peterlunger, Isabel& La Rosa, Valentina Lucia& Vitagliano, Amerigo& Noventa, Marco…[et al.]. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212131