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Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity
Joint Authors
Zhang, Feng
Wu, Qin
Liu, Jie
Wang, Guoqing
Huang, Chun
Lin, Fengqin
Lu, Disheng
Shi, Jing-Shan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease (PD) was one of the most common neurodegenerative diseases with a slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra (SN).
Neuroinflammation was identified to be an important contributor to PD pathogenesis with the hallmark of microglia activation.
Tetrahydroxystilbene glucoside (TSG) was the main active component extracted from Polygonum multiflorum and held amounts of pharmacological activities including antioxidant, free radical-scavenging, anti-inflammation, and cardioprotective properties.
Recent studies demonstrated that TSG exerted neuroprotection from several neurodegenerative disease models.
However, the underlying mechanisms were not completely elucidated.
In the present study, rat nigral stereotaxic injection of 6-hydroxydopamine- (6-OHDA-) elicited DA neuronal injury was performed to investigate TSG-mediated neuroprotection on DA neurons.
In addition, primary rat midbrain neuron-glia cocultures were applied to explore the mechanisms underlying TSG-exerted neuroprotection.
Results showed that daily intraperitoneal injection of TSG for 14 consecutive days significantly protected DA neurons from 6-OHDA-induced neurotoxicity and suppressed microglia activation.
Similar neuroprotection was shown in primary neuron-glia cocultures.
In vitro studies further demonstrated that TSG inhibited microglia activation and subsequent release of proinflammatory factors.
Moreover, TSG-mediated neuroprotection was closely related with the inactivation of mitogen-activated protein kinase (MAPK) signaling pathway.
Together, TSG protects DA neurons from 6-OHDA-induced neurotoxicity via the inhibition of microglia-elicited neuroinflammation.
These findings suggest that TSG might hold potential therapeutic effects on PD.
American Psychological Association (APA)
Huang, Chun& Lin, Fengqin& Wang, Guoqing& Lu, Disheng& Wu, Qin& Liu, Jie…[et al.]. 2018. Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212134
Modern Language Association (MLA)
Huang, Chun…[et al.]. Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212134
American Medical Association (AMA)
Huang, Chun& Lin, Fengqin& Wang, Guoqing& Lu, Disheng& Wu, Qin& Liu, Jie…[et al.]. Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212134