Effects of Valproate Monotherapy on the Oxidant-Antioxidant Status in Mexican Epileptic Children: A Longitudinal Study
Joint Authors
Floriano-Sánchez, Esaú
Cárdenas-Rodríguez, Noemí
Beltrán-Sarmiento, Eduardo
Arregoitia-Sarabia, Cindy K.
Sandoval-Pacheco, Roberto
Galván-Hernández, Diana E.
Ramos-Reyna, Eduardo
Rodríguez-Silverio, Juan
Coballase-Urrutia, Elvia
Carmona-Aparicio, Liliana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epilepsy is a neurological disorder that can produce brain injury and neuronal death.
Several factors such as oxidative stress have been implicated in epileptogenesis.
Valproic acid (VPA) is a widely used drug for the treatment of epilepsy, but the mechanisms underlying these benefits are complex and still not fully understood.
The objective of this study was to evaluate, for the first time, the effects of VPA on the oxidant-antioxidant status in Mexican epileptic children before and after 6 or 12 months of treatment with VPA by determining the activities of several plasmatic antioxidant enzymes (glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT)) and oxidant marker (malondialdehyde (MDA), hydrogen peroxide (H2O2), 8-hydroxy-2-deoxyguanosine (8-OHdG), and 3-nitrotyrosine (3-NT) levels) profiles.
The possible relationships between these markers and some clinicopathological factors were also evaluated.
Plasma samples were obtained from the peripheral blood of 16 healthy children and 32 patients diagnosed with epilepsy, and antioxidant/oxidant markers were measured spectrometrically.
Significant decreases in all antioxidant enzyme activities, with the exception of GPx, and increases in all oxidant markers in epileptic subjects versus healthy children were observed.
Interestingly, all these effects reverted after VPA monotherapy, although the results were different depending on the treatment period (6 or 12 months).
These changes were contingent upon brain imaging findings, type of epilepsy, etiology of epilepsy, and the efficacy of 6 months of VPA monotherapy.
Significant and positive correlations of GPx and SOD activities and H2O2 and 8-OHdG levels with the age of children at the beginning of treatment were observed.
H2O2 levels were also positively correlated with number of seizures before VPA monotherapy.
VPA showed significant antioxidant effects decreasing seizure activity, possibly depending on the presence of cerebral structural alterations, treatment time, and age.
American Psychological Association (APA)
Beltrán-Sarmiento, Eduardo& Arregoitia-Sarabia, Cindy K.& Floriano-Sánchez, Esaú& Sandoval-Pacheco, Roberto& Galván-Hernández, Diana E.& Coballase-Urrutia, Elvia…[et al.]. 2018. Effects of Valproate Monotherapy on the Oxidant-Antioxidant Status in Mexican Epileptic Children: A Longitudinal Study. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212136
Modern Language Association (MLA)
Beltrán-Sarmiento, Eduardo…[et al.]. Effects of Valproate Monotherapy on the Oxidant-Antioxidant Status in Mexican Epileptic Children: A Longitudinal Study. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212136
American Medical Association (AMA)
Beltrán-Sarmiento, Eduardo& Arregoitia-Sarabia, Cindy K.& Floriano-Sánchez, Esaú& Sandoval-Pacheco, Roberto& Galván-Hernández, Diana E.& Coballase-Urrutia, Elvia…[et al.]. Effects of Valproate Monotherapy on the Oxidant-Antioxidant Status in Mexican Epileptic Children: A Longitudinal Study. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212136