Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB
Joint Authors
Mialet-Perez, J.
Parini, A.
Miceli, Caterina
Nediani, Chiara
Manzella, Nicola
Santin, Yohan
Coppini, Raffaele
Berti, Andrea
Stefani, Massimo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Age-associated diseases such as neurodegenerative and cardiovascular disorders are characterized by increased oxidative stress associated with autophagy dysfunction.
Oleuropein aglycone (OA), the main polyphenol found in olive oil, was recently characterized as an autophagy inducer and a promising agent against neurodegeneration.
It is presently unknown whether OA can have beneficial effects in a model of cardiac stress characterized by autophagy dysfunction.
Here, we explored the effects of OA in cardiomyocytes with overexpression of monoamine oxidase-A (MAO-A).
This enzyme, by degrading catecholamine and serotonin, produces hydrogen peroxide (H2O2), which causes oxidative stress, autophagic flux blockade, and cell necrosis.
We observed that OA treatment counteracted the cytotoxic effects of MAO-A through autophagy activation, as displayed by the increase of autophagic vacuoles and autophagy-specific markers (Beclin1 and LC3-II).
Moreover, the decrease in autophagosomes and the increase in autolysosomes, indicative of autophagosome-lysosome fusion, suggested a restoration of the defective autophagic flux.
Most interestingly, we found that the ability of OA to confer cardioprotection through autophagy induction involved nuclear translocation and activation of the transcriptional factor EB (TFEB).
Our data provide strong evidence of the beneficial effects of OA, suggesting its potential use as a nutraceutical agent against age-related pathologies involving autophagy dysfunction, including cardiovascular diseases.
American Psychological Association (APA)
Miceli, Caterina& Santin, Yohan& Manzella, Nicola& Coppini, Raffaele& Berti, Andrea& Stefani, Massimo…[et al.]. 2018. Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212147
Modern Language Association (MLA)
Miceli, Caterina…[et al.]. Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212147
American Medical Association (AMA)
Miceli, Caterina& Santin, Yohan& Manzella, Nicola& Coppini, Raffaele& Berti, Andrea& Stefani, Massimo…[et al.]. Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212147