Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines
Joint Authors
Synowiec, Ewelina
Skała, Ewa
Sitarek, Przemysław
Śliwiński, Tomasz
Kowalczyk, Tomasz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rhaponticum carthamoides (Willd.) Iljin.
is an endemic plant species, which is important in Siberian medicine.
It possesses adaptogenic properties and has been used for treatment of overstrain and weakness after illness, physical weakness, and mental weariness.
The roots of this species obtained after Agrobacterium rhizogenes transformation are rich in caffeoylquinic acid derivatives known as strong antioxidant compounds.
The study makes the first evaluation of the cytotoxic and genotoxic activity of transformed root extract (Rc TR extract) in various human cancer cell lines: leukemia cells (K-562 and CCRF-CEM) and lung adenocarcinoma cells (A549).
It was found that Rc TR extract inhibited the cell viability of all tested cell lines in a concentration-dependent manner, and leukemia cell lines were more sensitive to plant extract than A549 lung cancer cell line.
Additionally, the Rc TR extract reduced the mitochondrial membrane potential and demonstrated genotoxicity against tested cell lines by increasing mitochondrial DNA lesions in ND1 and ND5 genes and causing nuclear DNA damage in TP53 gene.
Our results show that Rc TR extract may effectively treat cancer cells by inducing dysfunction of mitochondria.
Additionally, the role of mtDNA may be a promising factor in chemotherapy, and it needs further studies.
American Psychological Association (APA)
Skała, Ewa& Synowiec, Ewelina& Kowalczyk, Tomasz& Śliwiński, Tomasz& Sitarek, Przemysław. 2018. Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212165
Modern Language Association (MLA)
Skała, Ewa…[et al.]. Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212165
American Medical Association (AMA)
Skała, Ewa& Synowiec, Ewelina& Kowalczyk, Tomasz& Śliwiński, Tomasz& Sitarek, Przemysław. Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212165