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Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action
Joint Authors
Othman, Nor Hayati
Sulaiman, Siti Amrah
Ibrahim, Muhammad
Baig, Atif Amin
Liaqat, Sana
Fatima, Saira
Jabeen, Sadia
Shamim, Nighat
Ahmed, Sarfraz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-18
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Honey clasps several medicinal and health effects as a natural food supplement.
It has been established as a potential therapeutic antioxidant agent for various biodiverse ailments.
Data report that it exhibits strong wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic effects.
It also retains immunomodulatory, estrogenic regulatory, antimutagenic, anticancer, and numerous other vigor effects.
Data also show that honey, as a conventional therapy, might be a novel antioxidant to abate many of the diseases directly or indirectly associated with oxidative stress.
In this review, these wholesome effects have been thoroughly reviewed to underscore the mode of action of honey exploring various possible mechanisms.
Evidence-based research intends that honey acts through a modulatory road of multiple signaling pathways and molecular targets.
This road contemplates through various pathways such as induction of caspases in apoptosis; stimulation of TNF-α, IL-1β, IFN-γ, IFNGR1, and p53; inhibition of cell proliferation and cell cycle arrest; inhibition of lipoprotein oxidation, IL-1, IL-10, COX-2, and LOXs; and modulation of other diverse targets.
The review highlights the research done as well as the apertures to be investigated.
The literature suggests that honey administered alone or as adjuvant therapy might be a potential natural antioxidant medicinal agent warranting further experimental and clinical research.
American Psychological Association (APA)
Ahmed, Sarfraz& Sulaiman, Siti Amrah& Baig, Atif Amin& Ibrahim, Muhammad& Liaqat, Sana& Fatima, Saira…[et al.]. 2018. Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1212206
Modern Language Association (MLA)
Ahmed, Sarfraz…[et al.]. Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1212206
American Medical Association (AMA)
Ahmed, Sarfraz& Sulaiman, Siti Amrah& Baig, Atif Amin& Ibrahim, Muhammad& Liaqat, Sana& Fatima, Saira…[et al.]. Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1212206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212206