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Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation
Joint Authors
Monteiro, Marta Chagas
Lima, Rafael Rodrigues
Bittencourt, Leonardo Oliveira
Aragão, Walessa Alana Bragança
Nogueira, Lygia S.
Gomes, Bruno Alexandre Quadros
Miranda, Giza Hellen Nonato
Dionizio, Aline Salgado
Buzalaf, Marilia Afonso Rabelo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The excessive fluoride (F) exposure is associated with damage to cellular processes of different tissue types, due to changes in enzymatic metabolism and breakdown of redox balance.
However, few studies evaluate doses of F compatible with human consumption.
Thus, this study evaluated the effects of chronic exposure to sodium fluoride (NaF) on peripheral blood of mice from the evaluation of biochemical parameters.
The animals were divided into three groups (n=10) and received three concentrations of NaF in the drinking water for 60 days: 0 mg/L F, 10 mg/L F, and 50 mg/L F.
The blood was then collected for trolox equivalent antioxidant capacity (TEAC), thiobarbituric acid reactive substances (TBARS), concentrations of nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH).
The results showed that doses of 10 mg/L F and 50 mg/L F were able to increase TBARS concentration and decrease NO levels and CAT activity in the blood, but there was no statistical difference for SOD levels.
The 50 mg/L F group showed an increase in TEAC levels and a decrease in the GSH content when compared to the control group.
In this way, oxidative changes in blood from chronic exposure to F, especially at the highest dose, indicate that F may be a toxic agent and, therefore, the long-term exposure to excessive doses should be avoided.
American Psychological Association (APA)
Miranda, Giza Hellen Nonato& Gomes, Bruno Alexandre Quadros& Bittencourt, Leonardo Oliveira& Aragão, Walessa Alana Bragança& Nogueira, Lygia S.& Dionizio, Aline Salgado…[et al.]. 2018. Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212213
Modern Language Association (MLA)
Miranda, Giza Hellen Nonato…[et al.]. Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212213
American Medical Association (AMA)
Miranda, Giza Hellen Nonato& Gomes, Bruno Alexandre Quadros& Bittencourt, Leonardo Oliveira& Aragão, Walessa Alana Bragança& Nogueira, Lygia S.& Dionizio, Aline Salgado…[et al.]. Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212213