Role and Possible Mechanisms of Sirt1 in Depression
Joint Authors
Yan, Liang-Jun
Yang, Xiaorong
Lu, Guofang
Li, Jianguo
Zhang, Hongmei
Zhao, Xin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Depression is a common, devastating illness.
Due to complicated causes and limited treatments, depression is still a major problem that plagues the world.
Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD+ and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence.
Sirt1 has now become a critical therapeutic target for a number of diseases.
Recently, a genetic study has received considerable attention for depression and found that Sirt1 is a potential gene target.
In this short review article, we attempt to present an up-to-date knowledge of depression and Sirt1 of the sirtuin family, describe the different effects of Sirt1 on depression, and further discuss possible mechanisms of Sirt1 including glial activation, neurogenesis, circadian control, and potential signaling molecules.
Thus, it will open a new avenue for clinical treatment of depression.
American Psychological Association (APA)
Lu, Guofang& Li, Jianguo& Zhang, Hongmei& Zhao, Xin& Yan, Liang-Jun& Yang, Xiaorong. 2018. Role and Possible Mechanisms of Sirt1 in Depression. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212275
Modern Language Association (MLA)
Lu, Guofang…[et al.]. Role and Possible Mechanisms of Sirt1 in Depression. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212275
American Medical Association (AMA)
Lu, Guofang& Li, Jianguo& Zhang, Hongmei& Zhao, Xin& Yan, Liang-Jun& Yang, Xiaorong. Role and Possible Mechanisms of Sirt1 in Depression. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212275