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Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age
Joint Authors
Carrillo-Mora, Paul
González-Esquivel, Dinora
Ríos, Camilo
Ramírez-Ortega, Daniela
Ramos-Chávez, L. A.
Sánchez-Chapul, L.
Roldán-Roldán, G.
García-Juárez, B.
Pérez de la Cruz, G.
García Muñoz, I.
Jiménez Herrera, B.
Gómez-Manzo, S.
Marcial-Quino, J.
Pineda, Benjamín
Pérez-de la Cruz, Verónica
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aging is a physiological decline process.
The number of older adults is growing around the world; therefore, the incidence of cognitive impairment, dementia, and other diseases related to aging increases.
The main cellular factors that converge in the aging process are mitochondrial dysfunction, antioxidant impairment, inflammation, and immune response decline, among others.
In this context, these cellular changes have an influence on the kynurenine pathway (KP), the main route of tryptophan (Trp) catabolism.
KP metabolites have been involved in the aging process and neurodegenerative diseases.
Although there are changes in the metabolite levels with age, at this time, there is no study that has evaluated cognitive decline as a consequence of Trp catabolism fluctuation in aging.
The aim of this study was to evaluate the relation between the changes in Trp catabolism and cognitive impairment associated with age through KP metabolites level alterations in women over 50 years of age.
Seventy-seven nondemented women over 50 years old were examined with a standardized cognitive screening evaluation in Spanish language (Neuropsi), Beck anxiety inventory (BAI), and the geriatric depression scale (GDS).
Also, serum levels of Trp, kynurenine (Kyn), kynurenic acid (KYNA), and 3-hydroykynurenine (3-HK) and the glutathione ratio (GSH/GSSG) were measured.
Results showed a negative correlation between age and Trp levels and a positive correlation between age and KYNA/Trp and 3-HK/Trp ratios.
The level of cognitive impairment showed a significant positive association with age and with kynurenine pathway activation and a significant negative correlation with Trp levels.
The GSH/GSSG ratio correlated positively with Trp levels and negatively with Kyn/Trp and 3-HK/Trp ratios.
The depression score correlated negatively with Trp and positively with the 3-HK/Trp ratio.
We concluded that KP activation increases with age and it is strongly associated with the level of cognition performance in nondemented women over 50 years of age.
American Psychological Association (APA)
Ramos-Chávez, L. A.& Roldán-Roldán, G.& García-Juárez, B.& González-Esquivel, Dinora& Pérez de la Cruz, G.& Pineda, Benjamín…[et al.]. 2018. Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212285
Modern Language Association (MLA)
Ramos-Chávez, L. A.…[et al.]. Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212285
American Medical Association (AMA)
Ramos-Chávez, L. A.& Roldán-Roldán, G.& García-Juárez, B.& González-Esquivel, Dinora& Pérez de la Cruz, G.& Pineda, Benjamín…[et al.]. Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212285