Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme
Joint Authors
Al-Ghamdi, Saleh A.
Fawzy, Manal S.
Toraih, Eman A.
Al-Qahtani, Saeed Awad M.
Badran, Dahlia I.
Al Ageeli, Essam
Helal, Ghada M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment.
Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease.
The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas.
Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males).
Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification.
In silico network analysis was executed.
NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues.
Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2.
However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population.
In conclusion, the current study highlighted the aberrant expression of certain longevity-associated transcription factors in glioblastoma multiforme which may direct the attention towards new strategies in the treatment of such lethal disease.
American Psychological Association (APA)
Fawzy, Manal S.& Badran, Dahlia I.& Al Ageeli, Essam& Al-Qahtani, Saeed Awad M.& Al-Ghamdi, Saleh A.& Helal, Ghada M.…[et al.]. 2018. Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212309
Modern Language Association (MLA)
Fawzy, Manal S.…[et al.]. Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212309
American Medical Association (AMA)
Fawzy, Manal S.& Badran, Dahlia I.& Al Ageeli, Essam& Al-Qahtani, Saeed Awad M.& Al-Ghamdi, Saleh A.& Helal, Ghada M.…[et al.]. Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212309