![](/images/graphics-bg.png)
Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model
Joint Authors
Battistelli, Michela
Stocchi, Vilberto
Tiano, Luca
Marchini, Cristina
Amici, Augusto
Orlando, Patrik
Andreani, C.
Bartolacci, C.
Orlando, F.
Silvestri, S.
Provinciali, Mauro
Guescini, Michele
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Aging skeletal muscles are characterized by a progressive decline in muscle mass and muscular strength.
Such muscular dysfunctions are usually associated with structural and functional alterations of skeletal muscle mitochondria.
The senescence-accelerated mouse-prone 8 (SAMP8) model, characterized by premature aging and high degree of oxidative stress, was used to investigate whether a combined intervention with mild physical exercise and ubiquinol supplementation was able to improve mitochondrial function and preserve skeletal muscle health during aging.
5-month-old SAMP8 mice, in a presarcopenia phase, have been randomly divided into 4 groups (n=10): untreated controls and mice treated for two months with either physical exercise (0.5 km/h, on a 5% inclination, for 30 min, 5/7 days per week), ubiquinol 10 (500 mg/kg/day), or a combination of exercise and ubiquinol.
Two months of physical exercise significantly increased mitochondrial damage in the muscles of exercised mice when compared to controls.
On the contrary, ubiquinol and physical exercise combination significantly improved the overall status of the skeletal muscle, preserving mitochondrial ultrastructure and limiting mitochondrial depolarization induced by physical exercise alone.
Accordingly, combination treatment while promoting mitochondrial biogenesis lowered autophagy and caspase 3-dependent apoptosis.
In conclusion, the present study shows that ubiquinol supplementation counteracts the deleterious effects of physical exercise-derived ROS improving mitochondrial functionality in an oxidative stress model, such as SAMP8 in the presarcopenia phase.
American Psychological Association (APA)
Andreani, C.& Bartolacci, C.& Guescini, Michele& Battistelli, Michela& Stocchi, Vilberto& Orlando, F.…[et al.]. 2018. Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212318
Modern Language Association (MLA)
Andreani, C.…[et al.]. Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212318
American Medical Association (AMA)
Andreani, C.& Bartolacci, C.& Guescini, Michele& Battistelli, Michela& Stocchi, Vilberto& Orlando, F.…[et al.]. Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212318