The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
Joint Authors
Cui, Hong-Xin
Jia, Shan-Shan
Yuan, Ke
Luo, Yang
Jia, An
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Abelmoschus esculentus L.
has favorable nutritional/medicinal features.
We found the content of total flavonoids in flower extract to be the highest (788.56 mg/g) of all the different parts of A.
esculentus; according to high-performance liquid chromatography, the quercetin-3-O-[β-D-glu-(1 → 6)]-β-D-glucopyranoside content was 122.13 mg/g.
Protective effects of an extract of the total flavonoids of A.
esculentus flowers (AFF) on transient cerebral ischemia-reperfusion injury (TCI-RI) were investigated.
Compared with the model group, mice treated with AFF (300 mg/kg) for 7 days showed significantly reduced neurologic deficits, infarct area, and histologic changes in brain tissue, accompanied by increased contents of superoxide dismutase, whereas contents of nitric oxide and malondialdehyde decreased.
AFF upregulated the expression of Nrf2, HO-1, and NQO1.
These data suggest that AFF protects against TCI-RI by scavenging free radicals and activating the Nrf2-ARE pathway.
American Psychological Association (APA)
Luo, Yang& Cui, Hong-Xin& Jia, An& Jia, Shan-Shan& Yuan, Ke. 2018. The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212326
Modern Language Association (MLA)
Luo, Yang…[et al.]. The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212326
American Medical Association (AMA)
Luo, Yang& Cui, Hong-Xin& Jia, An& Jia, Shan-Shan& Yuan, Ke. The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212326