Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats
Joint Authors
Nwokocha, Chukwuemeka R.
Vega, José Luis
Benites, Julio
Salas, Felipe
Sandoval, Juan Marcelo
Palacios, Javier
Fonseca, José Miguel
Ayavire, Fernando
Ortiz, Mirko
Zavala, Ewaldo
Paredes, Adrián
Barría, Iván
Cifuentes, Fredi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Quinone derivatives like 2-(4-hydroxyphenyl) amino-1,4-naphthoquinone (Q7) are used as antitumor agents usually associated with adverse effects on the cardiovascular system.
The objective of this study was to evaluate the cardioprotective effect of ascorbate on Q7-induced cardiovascular response in Wistar rats.
In this study, blood pressure, vascular reactivity, and intracellular calcium fluxes were evaluated in cardiomyocytes and the rat aorta.
We also measured oxidative stress through lipid peroxidation (TBARS), superoxide dismutase- (SOD-) like activity, and H2O2 generation.
Oral treatment of rats with ascorbate (500 mg/kg) for 20 days significantly (p<0.05) reduced the Q7-induced increase (10 mg/kg) in blood pressure and heart rate.
The preincubation with ascorbate (2 mM) significantly (p<0.05) attenuated the irregular beating of the atrium induced by Q7 (10−5 M).
In addition, ascorbate induced endothelial vasodilation in the presence of Q7 in the intact aortic rings of a rat and reduced the cytosolic calcium levels in vascular smooth muscle cells.
Ascorbate also reduced the Q7-induced oxidative stress in vivo.
Ascorbate also attenuated Q7-induced SOD-like activity and increased TBARS levels.
These results suggest a cardioprotective effect in vivo of ascorbate in animals treated orally with a naphthoquinone derivative by a mechanism involving oxidative stress.
American Psychological Association (APA)
Palacios, Javier& Fonseca, José Miguel& Ayavire, Fernando& Salas, Felipe& Ortiz, Mirko& Sandoval, Juan Marcelo…[et al.]. 2018. Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212331
Modern Language Association (MLA)
Palacios, Javier…[et al.]. Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212331
American Medical Association (AMA)
Palacios, Javier& Fonseca, José Miguel& Ayavire, Fernando& Salas, Felipe& Ortiz, Mirko& Sandoval, Juan Marcelo…[et al.]. Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212331