Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S-Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity
Joint Authors
Napolitano, Alessandra
Panzella, Lucia
Officioso, Arbace
Tortora, Fabiana
Alfieri, Maria Laura
Manna, Caterina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is one of the underlying mechanisms of the toxic effects exerted by mercury (Hg) on human health.
Several antioxidant compounds, including the olive oil phenol hydroxytyrosol (HT), were investigated for their protective action.
Recently, we have reported that 5-S-lipoylhydroxytyrosol (Lipo-HT) has shown increased antioxidant activities compared to HT and exerted potent protective effects against reactive oxygen species (ROS) generation and oxidative damage in human hepatocellular carcinoma HepG2 cell lines.
In this study, the effects of Lipo-HT and HT on oxidative alterations of human erythrocytes induced by exposure to 40 μM HgCl2 were comparatively evaluated.
When administered to the cells, Lipo-HT (5–20 μM) proved nontoxic and it decreased the Hg-induced generation of ROS, the hemolysis, and the depletion of intracellular GSH levels.
At all tested concentrations, Lipo-HT exhibited higher ability to counteract Hg-induced cytotoxicity compared to HT.
Model studies indicated the formation of a mercury complex at the SH group of Lipo-HT followed by a redox reaction that would spare intracellular GSH.
Thus, the enhanced erythrocyte protective action of Lipo-HT from Hg-induced damage with respect to HT is likely due to an effective chelating and reducing ability toward mercury ions.
These findings encourage the use of Lipo-HT in nutraceutical strategies to contrast heavy metal toxicity in humans.
American Psychological Association (APA)
Officioso, Arbace& Panzella, Lucia& Tortora, Fabiana& Alfieri, Maria Laura& Napolitano, Alessandra& Manna, Caterina. 2018. Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S-Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212340
Modern Language Association (MLA)
Officioso, Arbace…[et al.]. Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S-Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212340
American Medical Association (AMA)
Officioso, Arbace& Panzella, Lucia& Tortora, Fabiana& Alfieri, Maria Laura& Napolitano, Alessandra& Manna, Caterina. Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S-Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212340