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Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding
Joint Authors
Xu, Biao
Xie, Jun
Wu, Han
Chen, Jian-Zhou
Chen, Zheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dysfunction of endothelial progenitor cells (EPCs) contributes to cardiovascular complications in diabetes, and resveratrol has been shown to improve EPC functions.
Syndecan-4 (Synd4), a cell surface heparin sulfate proteoglycan, has been shown to promote neovascularization.
Thus, the present study was performed to determine whether resveratrol promoted angiogenesis of EPCs by regulating Synd4.
Late EPCs were isolated from human peripheral blood and stimulated with AGEs.
Western blot showed that AGEs induced Synd4 shedding in a dose- and time-dependent manner.
AGE-induced Synd4 shedding was partly reversed by NAC or resveratrol, along with normalized ROS production.
Overexpression of Synd4 or pretreatment of resveratrol reversed AGE-impaired tube formation of EPCs and regulated the Akt/eNOS pathway.
Furthermore, resveratrol suppressed Synd4 shedding via the inhibition of oxidative stress and improved tube formation of late EPCs via the regulation of the Synd4/Akt/eNOS pathway.
American Psychological Association (APA)
Wu, Han& Chen, Zheng& Chen, Jian-Zhou& Xie, Jun& Xu, Biao. 2018. Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212342
Modern Language Association (MLA)
Wu, Han…[et al.]. Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212342
American Medical Association (AMA)
Wu, Han& Chen, Zheng& Chen, Jian-Zhou& Xie, Jun& Xu, Biao. Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212342