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Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model
Joint Authors
Picone, Pasquale
Nuzzo, Domenico
Galizzi, G.
Presti, G.
Gulotta, E.
Giuliano, S.
Mannino, C.
Gambino, V.
Scoglio, S.
Di Carlo, M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cyanobacteria have been recognized as a source of bioactive molecules to be employed in nutraceuticals, pharmaceuticals, and functional foods.
An extract of Aphanizomenon flos-aquae (AFA), commercialized as Klamin®, was subjected to chemical analysis to determine its compounds.
The AFA extract Klamin® resulted to be nontoxic, also at high doses, when administered onto LAN5 neuronal cells.
Its scavenging properties against ROS generation were evaluated by using DCFH-DA assay, and its mitochondrial protective role was determined by JC-1 and MitoSOX assays.
Klamin® exerts a protective role against beta amyloid- (Aβ-) induced toxicity and against oxidative stress.
Anti-inflammatory properties were demonstrated by NFβB nuclear localization and activation of IL-6 and IL-1β inflammatory cytokines through ELISA.
Finally, by using thioflavin T (ThT) and fluorimetric measures, we found that Klamin® interferes with Aβ aggregation kinetics, supporting the formation of smaller and nontoxic structures compared to toxic Aβ aggregates alone.
Altogether, these data indicate that the AFA extract may play a protective role against mechanisms leading to neurodegeneration.
American Psychological Association (APA)
Nuzzo, Domenico& Presti, G.& Picone, Pasquale& Galizzi, G.& Gulotta, E.& Giuliano, S.…[et al.]. 2018. Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212349
Modern Language Association (MLA)
Nuzzo, Domenico…[et al.]. Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212349
American Medical Association (AMA)
Nuzzo, Domenico& Presti, G.& Picone, Pasquale& Galizzi, G.& Gulotta, E.& Giuliano, S.…[et al.]. Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212349