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The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALBc Mice
Joint Authors
Zhang, Yining
Li, Qiujuan
Fang, Mengxiong
Ma, Yanmin
Liu, Na
Yan, Xiaomei
Zhou, Jie
Li, Fasheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
PM2.5 is well known as a major environmental pollutant; it has been proved to be associated with kidney diseases.
The kidney damage involves oxidative stress and/or inflammatory response.
NOX4 is a major source of reactive oxygen species (ROS) generation in the kidney, and the excessive generation of ROS is recognized to be responsible for oxidative stress.
To elucidate whether short-term PM2.5 exposure could induce kidney damage, we exposed BALB/c mice to PM2.5 intratracheally and measured the biomarkers of kidney injury (KIM-1, cystatin C), oxidative stress (MDA, SOD-1, and HO-1), and inflammatory response (NF-κB, TNF-α).
Acute kidney damage and excessive oxidative stress as well as transient inflammatory response were observed after PM2.5 installation.
The overexpression of some components of the angiotensin system (RAS) after PM2.5 exposure illustrated that RAS may be involved in PM2.5-induced acute kidney injury.
CEOs (compound essential oils) have been widely used because of their antioxidant and anti-inflammation properties.
Treatment with CEOs substantially attenuated PM2.5-induced acute kidney injury.
The suppression of RAS activation was significant and earlier than the decrease of oxidative stress and inflammatory response after CEOs treatment.
We hypothesized that CEOs could attenuate the acute kidney injury by suppressing the RAS activation and subsequently inhibit the oxidative stress and inflammatory response.
American Psychological Association (APA)
Zhang, Yining& Li, Qiujuan& Fang, Mengxiong& Ma, Yanmin& Liu, Na& Yan, Xiaomei…[et al.]. 2018. The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALBc Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212350
Modern Language Association (MLA)
Zhang, Yining…[et al.]. The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALBc Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212350
American Medical Association (AMA)
Zhang, Yining& Li, Qiujuan& Fang, Mengxiong& Ma, Yanmin& Liu, Na& Yan, Xiaomei…[et al.]. The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALBc Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212350