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Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways
Joint Authors
Nunez, Cecilia Veronica
Aparecida Paiva, Franciny
Boasquívis, Patrícia Ferreira
Silva, Giovanna Melo Martins
Cavalcanti, Rodrigo Marinho
de Paula Oliveira, Riva
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Guarana (Paullinia cupana) is largely consumed in Brazil in high energy drinks and dietary supplements because of its stimulant activity on the central nervous system.
Although previous studies have indicated that guarana has some protective effects in Parkinson’s (PD), Alzheimer’s (AD), and Huntington’s (HD) disease models, the underlying mechanisms are unknown.
Here, we investigated the protective effects of guarana hydroalcoholic extract (GHE) in Caenorhabditis elegans models of HD and AD.
GHE reduced polyglutamine (polyQ) protein aggregation in the muscle and also reduced polyQ-mediated neuronal death in ASH sensory neurons and delayed β-amyloid-induced paralysis in a caffeine-independent manner.
Moreover, GHE’s protective effects were not mediated by caloric restriction, antimicrobial effects, or development and reproduction impairment.
Inactivation of the transcription factors SKN-1 and DAF-16 by RNAi partially blocked the protective effects of GHE treatment in the AD model.
We show that the protective effect of GHE is associated with antioxidant activity and modulation of proteostasis, since it increased the lifespan and proteasome activity, reduced intracellular ROS and the accumulation of autophagosomes, and increased the expression of SOD-3 and HSP-16.2.
Our findings suggest that GHE has therapeutic potential in combating age-related diseases associated with protein misfolding and accumulation.
American Psychological Association (APA)
Boasquívis, Patrícia Ferreira& Silva, Giovanna Melo Martins& Aparecida Paiva, Franciny& Cavalcanti, Rodrigo Marinho& Nunez, Cecilia Veronica& de Paula Oliveira, Riva. 2018. Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1212365
Modern Language Association (MLA)
Boasquívis, Patrícia Ferreira…[et al.]. Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1212365
American Medical Association (AMA)
Boasquívis, Patrícia Ferreira& Silva, Giovanna Melo Martins& Aparecida Paiva, Franciny& Cavalcanti, Rodrigo Marinho& Nunez, Cecilia Veronica& de Paula Oliveira, Riva. Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1212365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212365