Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation
Joint Authors
Cai, Weiyang
Liu, Feng
Huang, Bo
Wang, Qian
Xu, Ming
Zhang, Yanjie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Gastric cancer, as a malignant epithelial tumor, is a major health threat leading to poor overall survival and death.
It is usually diagnosed at an advanced stage due to asymptomatic or only nonspecific early symptoms.
The present study demonstrated that gankyrin contributes to the early malignant transformation of gastric cancer and can be selected to predict the risk of gastric cancer in those patients harboring the precancerous lesions (dysplasia and intestinal metaplasia).
In addition, a new insight into gastric cancer was provided, which stated that gankyrin alleviates oxidative stress via mTORC1 pathway activation.
It can potentiate the mTORC1 by PGK1-AKT signaling that promotes the tumor process, and this phenomenon is not completely consistent with the previous report describing colorectal cancer.
American Psychological Association (APA)
Huang, Bo& Cai, Weiyang& Wang, Qian& Liu, Feng& Xu, Ming& Zhang, Yanjie. 2018. Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212384
Modern Language Association (MLA)
Huang, Bo…[et al.]. Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212384
American Medical Association (AMA)
Huang, Bo& Cai, Weiyang& Wang, Qian& Liu, Feng& Xu, Ming& Zhang, Yanjie. Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212384