Inhibition of HDAC6 Activity Alleviates Myocardial IschemiaReperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation
Joint Authors
Wu, Yang
Zhou, Bin
Leng, Yan
Qiu, Zhen
Wang, Kai
Lei, Shao-Qing
Xia, Zhong-Yuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Patients with diabetes are more vulnerable to myocardial ischemia/reperfusion (MI/R) injury, which is associated with excessive reactive oxygen species (ROS) generation and decreased antioxidant defense.
Histone deacetylase 6 (HDAC6), a regulator of the antioxidant protein peroxiredoxin 1 (Prdx1), is associated with several pathological conditions in the cardiovascular system.
This study investigated whether tubastatin A (TubA), a highly selective HDAC6 inhibitor, could confer a protective effect by modulating Prdx1 acetylation in a rat model of MI/R and an in vitro model of hypoxia/reoxygenation (H/R).
Here, we found that diabetic hearts with excessive HDAC6 activity and decreased acetylated-Prdx1 levels were more vulnerable to MI/R injury.
TubA treatment robustly improved cardiac function, reduced cardiac infarction, attenuated ROS generation, and increased acetylated-Prdx1 levels in diabetic MI/R rats.
These results were further confirmed by an in vitro study using H9c2 cells.
Furthermore, a study using Prdx1 acetyl-silencing mutants (K197R) showed that TubA only slightly attenuated H/R-induced cell death and ROS generation in K197R-transfected H9c2 cells exposed to high glucose (HG), but these differences were not statistically significant.
Taken together, these findings suggest that HDAC6 inhibition reduces ROS generation and confers a protective effect against MI/R or H/R injury by modulating Prdx1 acetylation at K197.
American Psychological Association (APA)
Leng, Yan& Wu, Yang& Lei, Shao-Qing& Zhou, Bin& Qiu, Zhen& Wang, Kai…[et al.]. 2018. Inhibition of HDAC6 Activity Alleviates Myocardial IschemiaReperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212386
Modern Language Association (MLA)
Leng, Yan…[et al.]. Inhibition of HDAC6 Activity Alleviates Myocardial IschemiaReperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212386
American Medical Association (AMA)
Leng, Yan& Wu, Yang& Lei, Shao-Qing& Zhou, Bin& Qiu, Zhen& Wang, Kai…[et al.]. Inhibition of HDAC6 Activity Alleviates Myocardial IschemiaReperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212386